Ganglions are a small cystic tumor containing viscid fluid and are non-malignant growths that usually forms near the joints and tendons of the hand and wrist. They are harmless and non-cancerous growth, mostly asymptomatic. Pain, tenderness, annoyance with cosmetic appearance associated with some cases. Though homoeopathic literature enlists many medicines for wrist ganglion, there is paucity of evidence based published studies. The patients presented with the complaints of firm to hard swelling at the dorsum of hand. After meticulous case taking, analysis and evaluation of the symptoms followed by Repertorization of the characteristics, the similimum was selected. A single, simple medicine with minimum dose was administered in each case followed by placebo. Four cases were treated with Phosphorus 200, Calcarea carbonica 1M, Phosphorus 1M and Sulphur 200 respectively. Single dose of medicines was administered as per cardinal principles of homoeopathy and waited for 3 months. Striking improvement in symptomatology was noted after the course of treatment. Homoeopathic medicines selected on the basis of strict individualization showed promising result in all four cases. Patients reported reduction of symptoms as well as general wellbeing following the treatment. Further studies with sound methodology are suggested to evaluate the efficacy of larger spectrum of homoeopathic medicines in the treatment of wrist ganglion.