Background: The procedure of Hematopoietic cell transplantation (HCT) is associated with a significant risk of morbidity and mortality and, consequently, significant distress in the HCT recipients. Few mindfulness-based interventions (MBI) in HCT recipients had heterogeneous intervention practices and equally heterogeneous tools to measure outcomes. While preliminary studies showed the feasibility and usefulness of MBI, subsequent randomized controlled trials were flawed by low intervention uptake and no differences in outcomes. We propose a simple and acceptable MBI using an app that may ensure better adherence. Summary: We propose a randomized controlled trial (RCT) where HCT recipients in the intervention arm will be initiated into awareness using ‘Inner engineering’ online and practice self-guided mindfulness meditation (Isha Kriya) using an app. The outcomes will measure the global and subdomain (physical, social/family, functional, emotional, and BMT-specific) quality of life (QoL) using validated HCT questionnaires such as the Functional Assessment of Cancer Therapy – Bone Marrow Transplantation (FACT-BMT) and Patient-Reported Outcomes Measurement Information System – Global Health (Adult version) (PROMIS-GH). Key massage: The primary endpoint would be a change in the BMT-specific subdomain of the FACT-BMT questionnaire and the secondary endpoint would be a change in the FACT-BMT total scores and global health scores and adherence to MBI. Should the study endpoints be met, the practicality and usefulness of MBI in the HCT setting will be confirmed in this study.