Chronic Low Back pain (CLBP) is common public health problem, and globally one of the leading cause of disability. Several research studies advocate Yoga may add on as an effective therapy for CLBP patients. The present case study is an attempt to elucidate the outcome of Integrated Approach of Yoga Therapy (IAYT) intervention (which included loosening practices, asanas with breathing, relaxation, pranayama and meditation techniques) as an adjunct and integrative therapy to reduce pain symptoms, pain-associated disability and their overall quality of life in CLBP adult patients. The manuscript illustrates the two CLBP patients, refractory to conservative management, visiting pain clinic at Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Both the patients received a series of 60 minutes IAYT class conducted for a span of 15 days along with the institutional usual care regime as their treatment protocol. Patients were evaluated at baseline, 1 month and 3 month using various assessment tools (for pain intensity, disability, neuropathic pain component, quality of life, pain experiences, mental health, fear of movements and overall clinical benefit). Both the patients showed steady and gradual progression in reducing their pain intensity and its associated disability, quality of life and mental health. The patients narrated their experience and their ability to manage bio-psycho-socio aspects associated with CLBP. They attributed their positive changes to IAYT protocol.