Background: Anjananamika is one of the Vartmagata, Raktapradhana, Sadhya Netra Vikaras. These symptoms resemble nodular swelling on the eyelid. A stye, also known as hordeolum, is a common condition of the eye seen in ophthalmology and general medicine OPDs. Classically, a hordeolum usually appears as a little pustule on the edge of the eyelid. One of the most prevalent forms of eyelid lesions observed in the ophthalmology clinic is chalazion. It is a long-lasting, lipogranulomatous inflammatory lesion brought on by the Meibomian gland obstruction. Management of Anjananamika in Ayurveda classics consists of Swedana, Bhedana and Pratisarana. Although Pindi is not mentioned directly in the treatment modality of Anjananamika, Pindi can be taken as a form of Swedana. It works by absorbing substances through the transdermal route. Since the appendages are not notably present over the eye lid skin, the thinner stratum corneum of the eye lid skin indicates lower resistance, which may be the cause of higher drug absorption through the eye lid skin. The majority of absorption happens through the skin. Method: Study type is a Randomized comparative clinical study, the timing was prospective. Masking was open label, and grouping was double arm. Randomization was done by lottery method and group intervention method was parallel. The nature of Subjects presenting with the classical features of Anjananamika as described under diagnostic criteria. Subjects between the ages of 21 and 60, regardless of gender, occupation, religion, socioeconomic back-ground, or duration of illness. Subjects willing to participate with written informed consent, which is conveyed in the language which the subject can understand. Result: 40 patients registered for the study were randomly allocated to two groups A and B with 20 patients each. Within the group anal-ysis shows that both the groups have highly significant results i.e., progressive decrease in symptoms. The comparative analysis between the groups showed no significant results except for Kandu (p = 0.047). Yuvraj Sutar, Ajitkumar S Herwade, Late Kedari Redekar. To study efficacy of Rasanjantrikatu lepa on Anjannamika with special reference to Hordeolum externum. Total 60 patients were selected for study. Two groups, 30 patients in each group having Lakshanas of Anjananamika were selected. Though significant relief provided by drugs of both groups, in Lakshanas like Kandu (itching), the Rasanjantrikatu Lepa turns more effective. The primary Objective of the study was to evaluate the efficacy of Guduchi Pindi in the management of Anjananamika based on treatment outcome related to swelling, pain, burning sensation, itching and pricking sensation and thereafter, to re-evaluate the efficacy of Nimbadi Pindi in the management of Anjananamika based on treatment outcome related to swelling, pain, burning sensation, itching and pricking sensation. The secondary objective of the study was to compare the efficacy of Guduchi Pindi with that of Nimbadi Pindi in the management Anjananamika. Conclusion: In the present study no adverse drug reaction was reported thus no rescue medications were given. Guduchi has Rakta and Pittahara properties, and is also present in the Daha Prashamana Gana, due to which it may have reduced Daha. Kandu may have reduced due to its Kandughna and Tridoshahara properties, whereas Toda and Ruja may have reduced by its Ushna Veerya and Tridoshahara properties. Swelling may have reduced by the Tridoshahara, Krimihara properties of Guduchi.