Psoriasis is an aggressive and widespread chronic, recurring, immune-mediated skin condition. This significantly harms the affected patient's physical, emotional, and psychosocial wellness. As a result of the restricted therapeutic options for psoriasis in traditional practice, an alternate system of approach is necessary. A 57 years old male presented with papulosquamous skin lesions with excessive white scaling for 10 years. After careful clinical evaluation, the case was diagnosed with Plaque Psoriasis. Going through the individualistic approach of Homoeopathy Arsenicum iodatum was prescribed in 50 millesimal potencies. Clinically, the improvement was consistent and evident as the reduction in Psoriasis Area and Severity Index (PASI) score. The case revealed a commending therapeutic efficacy of Individualised Homoeopathic treatment in Plaque Psoriasis. A 10 years duration autoimmune skin lesion was relieved within a very shorter span of treatment and not recurred after 10 months of the last medication. Thus, through this case, homoeopathic medicine showed a complete recovery of Plaque Psoriasis nullifying the tendency of recurrence. For any other conclusion regarding causal attribution, a large-scale randomised controlled trial is required.