General health Status and Tridosha analysis of urban high-risk Diabetes after 3- month Diabetes Yoga Protocol: a pilot study
Kalyan Maity, Navneet Kaur, Rakesh Malik, Gurmeet Singh, Neeru Malik
Keywords :
Anxiety, Quality of Life, Tridosha, Diabetes Yoga Protocol, Urban population, Indian Diabetes Risk Score
Citation Information :
Maity K, Kaur N, Malik R, Singh G, Malik N. General health Status and Tridosha analysis of urban high-risk Diabetes after 3- month Diabetes Yoga Protocol: a pilot study. Integr Med Case Rep 2022; 3 (1):4-11.
Background and Purpose: Stress and anxiety have been closely related to insulin resistance, early appearance of diabetes, and enhanced diabetes progression. Stress and anxiety also have a negative effect on patients' general health status and quality of life. In earlier study Yoga has been proven as an effective intervention for prevention, treatment, risk reduction of diabetes, preventing conversion from prediabetes to diabetes, and reducing diabetes complications. The present study was aimed to identify the diabetes high-risk population and to analyze the effect of 3-month DYP on General health, anxiety, quality of life, and Tridosha in the urban high risk for diabetes population.
Method: A total of 12 participants were selected for the present study based on inclusion and exclusion criteria and screened through the IDRS scale. Five participants were included in the study based on IDRS score (≥60). General health, quality of life, State and Trait Anxiety, and Tridosha were measured at baseline and after 3 months of Diabetes Yoga Protocol by self-administrated questionnaires.
Result: Results showed significant reduction in STAI (p = 0.001) and significant improvement in GHQ-12 (p = 0.022*), Physical health (p = 0.018*), Psychological health (p = <0.001), Environment (p = <0.001), Total WHOQOL (p = 0.001), Vata (p = 0.007**), Pitta (p = 0.032*) and total Tridosha (p = 0.002**) score after 3-month of DYP.
Conclusion: DYP helps in improving, not only the general health, quality of life but also reduces the anxiety levels and Tridosha scores in the urban high-risk Diabetic population.
Daar AS, Singer PA, Persad DL, Pramming SK, Matthews DR, Beaglehole R, Bernstein A, Borysiewicz LK, Colagiuri S, Ganguly N, Glass RI. Grand challenges in chronic non-communicable diseases. Nature. 2007 Nov;450(7169):494–6.
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care. 2004 May 1;27(5):1047–53.
Buchberger B, Huppertz H, Krabbe L, Lux B, Mattivi JT, Siafarikas A. Symptoms of depression and anxiety in youth with type 1 diabetes: A systematic review and meta-analysis. Psychoneuroendocrinology. 2016 Aug 1;70:70–84.
Ruissen MM, Regeer H, Landstra CP, Schroijen M, Jazet I, Nijhoff MF, Pijl H, Ballieux BE, Dekkers O, Huisman SD, de Koning EJ. Increased stress, weight gain and less exercise in relation to glycemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic. BMJ Open Diabetes Research and Care. 2021 Jan 1;9(1):e002035.
Meigs JB, Larson MG, Fox CS, Keaney JF, Vasan RS, Benjamin EJ. Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Diabetes care. 2007 Oct 1;30(10):2529–35.
Almawi WY, Tamim H, Al-Sayed N, Arekat MR, Al-Khateeb GM, Baqer A, Tutanji H, Kamel C. Association of comorbid depression, anxiety, and stress disorders with Type 2 diabetes in Bahrain, a country with a very high prevalence of Type 2 diabetes. Journal of endocrinological investigation. 2008 Nov;31(11):1020–4.
Hackett RA, Steptoe A. Type 2 diabetes mellitus and psychological stress—a modifiable risk factor. Nature Reviews Endocrinology. 2017 Sep;13(9):547–60.
Deschênes SS, Burns RJ, Graham E, Schmitz N. Prediabetes, depressive and anxiety symptoms, and risk of type 2 diabetes: a community-based cohort study. Journal of psychosomatic research. 2016 Oct 1;89:85–90.
Long Q, Guo J, Zhong Q, Jiang S, Wiley J, Chen JL. General self-efficacy and social support as mediators of the association between perceived stress and quality of life among rural women with previous gestational diabetes mellitus. Journal of clinical nursing. 2021 Apr;30(7-8):1026–36.
Rodríguez-Almagro J, García-Manzanares Á, Lucendo AJ, Hernández-Martínez A. Health-related quality of life in diabetes mellitus and its social, demographic and clinical determinants: A nationwide cross-sectional survey. Journal of clinical nursing. 2018 Nov;27(21-22):4212–23.
Maity K, Nagarathna R, Anand A, Patil SS, Singh A, Rajesh SK, Ramesh L, Sridhar P, Thakur UK, Nagendra HR. Sleep Disorders in Individuals With High Risk for Diabetes in Indian Population. Annals of Neurosciences. 2021 Apr 24:0972753121998470.
Fukuoka Y, Lindgren TG, Bonnet K, Kamitani E. Perception and sense of control over eating behaviors among a diverse sample of adults at risk for type 2 diabetes. The Diabetes Educator. 2014 May;40(3):308–18.
Rimm EB, Manson JE, Stampfer MJ, Colditz GA, Willett WC, Rosner B, Hennekens CH, Speizer FE. Cigarette smoking and the risk of diabetes in women. American journal of public health. 1993 Feb;83(2):211–4.
Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. Jama. 2007 Dec 12;298(22):2654–64.
Alcohol consumption and diabetes risk in the Diabetes Prevention Program. The American journal of clinical nutrition. 2009;90(3), pp. 595–601.
Cullmann M, Hilding A, Östenson CG. Alcohol consumption and risk of pre-diabetes and type 2 diabetes development in a Swedish population. Diabetic Medicine. 2012 Apr;29(4):441–52.
Paul L, Ellis BM, Leese GP, McFadyen AK, McMurray B. The effect of a cognitive or motor task on gait parameters of diabetic patients, with and without neuropathy. Diabetic Medicine. 2009 Mar;26(3):234–9.
Liu XC, Pan L, Hu Q, Dong WP, Yan JH, Dong L. Effects of yoga training in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Journal of thoracic disease. 2014 Jun;6(6):795.
Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V. The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia. 2006 Feb;49(2):289–97.
Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine. 2001 May 3;344(18):1343–50.
Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New England journal of medicine. 2002 Feb 7;346(6):393–403.
Raveendran AV, Deshpandae A, Joshi SR. Therapeutic role of yoga in type 2 diabetes. Endocrinology and Metabolism. 2018 Sep 1;33(3):307–17.
Shantakumari N, Sequeira S. Effects of a yoga intervention on lipid profiles of diabetes patients with dyslipidemia. Indian heart journal. 2013 Mar 1;65(2):127–31.
Yadav A, Kaushik RM, Kaushik R. Effects of Diaphragmatic Breathing and Systematic Relaxation on Depression, Anxiety, Stress, and Glycemic Control in Type 2 Diabetes Mellitus. International journal of yoga therapy. 2021;31(1):Article_13.
Echouffo-Tcheugui JB, Dagogo-Jack S. Preventing diabetes mellitus in developing countries. Nature Reviews Endocrinology. 2012 Sep;8(9):557–62.
de GR Hansen E, Innes K. The benefits of yoga for adults with type 2 diabetes: a review of the evidence and call for a collaborative, integrated research initiative. International journal of yoga therapy. 2013 Jan 1;23(2):71–83.
Chattopadhyay K, Mishra P, Manjunath NK, Harris T, Hamer M, Greenfield S, Wang H, Singh K, Lewis SA, Tandon N, Kinra S. Development of a Yoga programme for type-2 diabetes prevention (YOGA-DP) among high-risk people in India. Frontiers in public health. 2020;8:688.
Chattopadhyay K, Mishra P, Singh K, Harris T, Hamer M, Greenfield SM, Lewis SA, Manjunath NK, Nair R, Mukherjee S, Harper DR. Yoga programme for type-2 diabetes prevention (YOGA-DP) among high risk people in India: a multicentre feasibility randomised controlled trial protocol. BMJ open. 2020 Sep 1;10(9):e036277.
McDermott KA, Rao MR, Nagarathna R, Murphy EJ, Burke A, Nagendra RH, Hecht FM. A yoga intervention for type 2 diabetes risk reduction: a pilot randomized controlled trial. BMC complementary and alternative medicine. 2014 Dec;14(1):1–4.
Popli U, Subbe CP, Sunil K. the role of yoga as a lifestyle modification in treatment of diabetes mellitus: results of a pilot study. Alternative therapies in health and medicine. 2014 Nov 1;20(6):24–6.
Amita S, Prabhakar S, Manoj I, Harminder S, Pavan T. Short communication effect of yoga-nidra on blood glucose level in diabetic patients. Indian Journal of Physiol Pharmacol. 2009;53(1):97–101.
Lindström J, Peltonen M, Eriksson JG, Louheranta A, Fogelholm M, Uusitupa M, Tuomilehto J. High-fibre, low-fat diet predicts long-term weight loss and decreased type 2 diabetes risk: the Finnish Diabetes Prevention Study. Diabetologia. 2006 May;49(5):912–20.
Ali MK, Echouffo-Tcheugui JB, Williamson DF. How effective were lifestyle interventions in real-world settings that were modeled on the Diabetes Prevention Program?. Health affairs. 2012 Jan 1;31(1):67–75.
Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V. The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia. 2006 Feb;49(2):289–97.
Balkrishna A. A practical approach to the science of ayurveda: a comprehensive guide for healthy living. Haridwar, India: Divya Prakashan, Divya Yoga Mandir Trust; 2013.
Sumantran VN, Tillu G. Cancer, inflammation, and insights from ayurveda. Evidence-Based Complementary and Alternative Medicine. 2012 Jan 1;2012.
Kumar PV, Deshpande S, Joshi A, More P, Nagendra HR. Association of arterial stiffness measured from Tridoshas with diabetes− A cross sectional study. J Ayu Herb Med. 2016;2(6):218–23.
Sivapuram MS, Srivastava V, Kaur N, Anand A, Nagarathna R, Patil S, Biman S, Chander I, Jyoti S, Nagendra HR. Ayurveda Body–Mind Constitutional Types and Role of Yoga Intervention Among Type 2 Diabetes Mellitus Population of Chandigarh and Panchkula Regions. Annals of Neurosciences. 2020 Jul;27(3-4):214–23.
Maity K, Kaur N, Rain M, Malik R, Vinayak R, Ahuja S, Malik N. Biochemical and neuropsychological effect of diabetes yoga protocol on urban high-risk diabetes population: a pilot study. The journal of oriental research madras. 2022: XCIII-I:49–60.
Nagarathna R, Tyagi R, Battu P, Singh A, Anand A, Nagendra HR. Assessment of risk of diabetes by using Indian Diabetic risk score (IDRS) in Indian population. Diabetes research and clinical practice. 2020 Apr 1;162:108088.
Mohan V, Deepa R, Deepa M, Somannavar S, Datta M. A simplified Indian Diabetes Risk Score for screening for undiagnosed diabetic subjects. Journal of the Association of Physicians of India. 2005;53:759–63.
Gureje O, Obikoya B. The GHQ-12 as a screening tool in a primary care setting. Social psychiatry and psychiatric epidemiology. 1990 Sep;25(5):276–80.
Spielberger CD. State-Trait anxiety inventory. The Corsini encyclopedia of psychology. 2010 Jan 30:1.
World Health Organization. WHOQOL-BREF: introduction, administration, scoring and generic version of the assessment: field trial version, December 1996. World Health Organization; 1996.
Hankey A. Establishing the scientific validity of Tridosha part 1: Doshas, Subdoshas and Dosha Prakritis. Ancient science of life. 2010 Jan;29(3):6.
Shilpa S, Murthy CV. Development and standardization of Mysore Tridosha scale. Ayu. 2011 Jul;32(3):308.
Kaur N, Malik N, Mathur D, Pal S, Malik R, Rana S. Mindfulness and yoga halt the conversion of pre-diabetic rural women into diabetics-a pilot study. Integr. Med. Case Rep. 2020;1:8–18.
Guillén-Riquelme A, Buela-Casal G. Meta-analysis of group comparison and meta-analysis of reliability generalization of the State-Trait Anxiety Inventory Questionnaire (STAI). Revista espanola de salud publica. 2014 Jan 1;88(1):101–12.
Vizcaino M. Hatha yoga practice for type 2 diabetes mellitus patients: a pilot study. International journal of yoga therapy. 2013 Jan 1;23(2):59–65.
Singh VP, Khandelwal B. Effect of yoga and exercise on glycemic control and psychosocial parameters in type 2 diabetes mellitus: A randomized controlled study. International Journal of Yoga. 2020 May;13(2):144.
Kashyap GC, Singh SK. Reliability and validity of general health questionnaire (GHQ-12) for male tannery workers: a study carried out in Kanpur, India. BMC psychiatry. 2017 Dec;17(1):1–7.
Kukihara H, Yamawaki N, Ando M, Nishio M, Koga K, Kimura H, Matsuda T. Effects of exercise and mindfulness-based yoga programs on promotion of resilience and mental health of older adults in japan: A randomized controlled trial. Psychology. 2020 Feb 7;11(2):285–98.
Rao M, Metri K, Raghuram N, Nagendra HR. Effects of Mind Sound Resonance Technique (Yogic Relaxation) on Psychological States, Sleep Quality, and Cognitive Functions in Female Teachers: A Randomized, Controlled Trial. Advance Winter. 2017; 31(1):4–9.
Whoqol Group. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychological medicine. 1998 May;28(3):551–8.
Kaur N, Malik N, Mathur D, Pal S, Malik R, Rana S. Mindfulness and yoga halt the conversion of pre-diabetic rural women into diabetics-a pilot study. Integr. Med. Case Rep. 2020;1:8–18.
Jyotsna VP, Joshi A, Ambekar S, Kumar N, Dhawan A, Sreenivas V. Comprehensive yogic breathing program improves quality of life in patients with diabetes. Indian journal of endocrinology and metabolism. 2012 May;16(3):423.
Pascoe MC, Bauer IE. A systematic review of randomised control trials on the effects of yoga on stress measures and mood. Journal of psychiatric research. 2015 Sep 1;68:270–82.
Thind H, Lantini R, Balletto BL, Donahue ML, Salmoirago-Blotcher E, Bock BC, Scott-Sheldon LA. The effects of yoga among adults with type 2 diabetes: A systematic review and meta-analysis. Preventive medicine. 2017 Dec 1;105:116–26.
Yang HJ, Koh E, Sung MK, Kang H. Changes Induced by Mind–Body Intervention Including Epigenetic Marks and Its Effects on Diabetes. International Journal of Molecular Sciences. 2021 Jan;22(3):1317.
Gowri MM, Rajendran J, Srinivasan AR, Bhavanani AB, Meena R. Impact of an Integrated Yoga Therapy Protocol on Insulin Resistance and Glycemic Control in Patients with Type 2 Diabetes Mellitus. Rambam Maimonides Medical Journal. 2022 Jan;13(1).
Bock BC, Thind H, Fava JL, Dunsiger S, Guthrie KM, Stroud L, Gopalakrishnan G, Sillice M, Wu W. Feasibility of yoga as a complementary therapy for patients with type 2 diabetes: the Healthy Active and in Control (HA1C) study. Complementary therapies in medicine. 2019 Feb 1;42:125–31.
Keerthi GS, Pal P, Pal GK, Sahoo JP, Sridhar MG, Balachander J. Effect of 12 Weeks of yoga therapy on quality of life and Indian diabetes risk score in normotensive Indian young adult prediabetics and diabetics: randomized control trial. Journal of clinical and diagnostic research: JCDR. 2017 Sep;11(9):CC10.
Hankey A. Ayurvedic physiology and etiology: Ayurvedo Amritanaam. The doshas and their functioning in terms of contemporary biology and physical chemistry. The Journal of Alternative & Complementary Medicine. 2001 Oct 1;7(5):567–74.
Anand A, Gupta PK, Sharma NK, Prabhakar S. Soluble VEGFR1 (sVEGFR1) as a novel marker of amyotrophic lateral sclerosis (ALS) in the North Indian ALS patients. European Journal of Neurology. 2012 May;19(5):788–92.
Gupta PK, Prabhakar S, Abburi C, Sharma NK, Anand A. Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients. Journal of neuroinflammation. 2011 Dec;8(1):1–6.
Kamal Sharma N, Gupta A, Prabhakar S, Singh R, Sharma S, Anand A. Single nucleotide polymorphism and serum levels of VEGFR2 are associated with age related macular degeneration. Current neurovascular research. 2012 Nov 1;9(4):256–65.
Anand A, Sharma NK, Gupta A, Prabhakar S, Sharma SK, Singh R, Gupta PK. Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular degeneration. PloS one. 2012 Nov 21;7(11):e49905.
Sharma NK, Gupta A, Prabhakar S, Singh R, Sharma SK, Chen W, Anand A. Association between CFH Y402H polymorphism and age related macular degeneration in North Indian cohort. PloS one. 2013 Jul 29;8(7):e70193.
Anand A, Tyagi R, Mohanty M, Goyal M, De Silva KR, Wijekoon N. Dystrophin induced cognitive impairment: mechanisms, models and therapeutic strategies. Annals of neurosciences. 2015 Apr;22(2):108.
Banik A, Brown RE, Bamburg J, Lahiri DK, Khurana D, Friedland RP, Chen W, Ding Y, Mudher A, Padjen AL, Mukaetova-Ladinska E. Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome? 1. Journal of Alzheimer's Disease. 2015 Jan 1;47(4):815–43.
Anand A, Banik A, Thakur K, L Masters C. The animal models of dementia and Alzheimer's disease for pre-clinical testing and clinical translation. Current Alzheimer Research. 2012 Nov 1;9(9):1010–29.
Goyal K, Koul V, Singh Y, Anand A. Targeted drug delivery to central nervous system (CNS) for the treatment of neurodegenerative disorders: trends and advances. Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents). 2014 Apr 1;14(1):43–59.
Vinish M, Prabhakar S, Khullar M, Verma I, Anand A. Genetic screening reveals high frequency of PARK2 mutations and reduced Parkin expression conferring risk for Parkinsonism in North West India. Journal of Neurology, Neurosurgery & Psychiatry. 2010 Feb 1;81(2):166–70.