Citation Information :
Sabharwal P, Fagen J, Dada R, Sharma A, Kaushik CS, Chaturvedi A, Bhardwaj P. Integrating bioinformatics and epigenetics with Ayurveda-a possible contribution towards COVID-19 fight. Integr Med Case Rep 2020; 1 (2):39-44.
Background: The entire world is struggling from the COVID-19 pandemics. Scientific community all around the world have been looking for any possible measure to fight against this dreadful disease. Ayurveda, the traditional Indian system of medicine, has immense potential to contribute towards this pandemic both in prevention and management. But Ayurveda fraternity has the challenge to explain the available possible measures in contemporary language. The science of bioinformatics & epigenetics has provided possibility for scientific & contemporary explanation of Ayurvedic interventions.
Summary: This paper is an attempt to discuss about various possibilities and challenges from Ayurveda perspective against COVID-19 in the purview of Ayurinformatics and Epigenetics.
Key messages: Ayurinformatics have been applied successfully earlier to infectious diseases & scientists have screened many phytochemicals from medicinal plants in silico against covid 19. Further with the advance knowledge of epigenetics, intervention of Ayurveda on different expressed variants of coronavirus with intervention of screened phytochemicals discovered in silico with the knowledge of science of ayurinformatics will certainly contribute towards the fight with covid 19.
Hui DS, Azhar EI, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China. International Journal of Infectious Diseases. 2020;91:264–6.
“WHO Director-General's opening remarks at the media briefing on COVID-19”. World Health Organization (WHO) (Press release). 11 March 2020. Retrieved 12 March 2020.
Gavande S, Mane J. Role of Ayurved in Epidemic Diseases Due to World War-A Critical Review. International Journal of Science and Research. 2014;5(2).
Shukla N. Ayurvedic Approach to Communicable Disease – An Overview. Journal of Community Medicine & Health Education. 2012;01(S1).
Samal J. Fundamental tenets of epidemiology in Ayurveda and their contemporary relevance. Indian Journal of Health Sciences. 2016;9(1):20.
Bano N, Ahmed A, Tanveer M, Khan Gm, Ansari MT. Pharmacological Evaluation of Ocimum sanctum. J Bioequiv Availab. 2017;9:387–392
Samal J. Fundamental tenets of epidemiology in Ayurveda and their contemporary relevance. Indian Journal of Health Sciences. 2016;9(1):20.
Bhushan Patwardhan, Preeti Chavan-Gautam, Manish Gautam, Girish Tillu, Arvind Chopra, Sunil Gairola et al. Ayurvedarasayana in prophylaxis of COVID-19. Current Science, 2020
J Cinatl, B Morgenstern, G Bauer, P Chandra, H Rabenau, H Doerr. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet. 2003;361(9374):2045–2046.
Hoever G, Baltina L, Michaelis M, Kondratenko R, Baltina L, Tolstikov G et al. Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS−Coronavirus. Journal of Medicinal Chemistry. 2005;48(4):1256–1259.
Mounce B, Cesaro T, Carrau L, Vallet T, Vignuzzi M. Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding. Antiviral Research. 2017;142:148–157.
Lin L, Hsu W, Lin C. Antiviral Natural Products and Herbal Medicines. Journal of Traditional and Complementary Medicine. 2014;4(1):24–35.
Atilla Çifci, Cüneyt Tayman, Halil ıbrahim, Yakut, Halit Halil, Esra Çakır, Ufuk Çakır, Salih Aydemir. Ginger (Zingiberofficinale) prevents severe damage to the lungs due to hyperoxia and inflammation. Turkish journal of medical sciences. 2018;48(4).
Ahmad, A, M. R. Javed, A. Q. Rao and T. Husnain. “Designing and screening of universal drug from neem (Azadirachtaindica) and standard drug chemicals against influenza virus nucleoprotein.” BMC Complementary and Alternative Medicine; 2016;16(1).
Rani P, Sharma K, Kumar K. Probable mode of action of sanjivanivati – a critical review. Int J Health Sci Res. 2018;8(8):295–307.
Singh A, Agrawal K, Dadhich OP. Pharmacodynamics of Shatyadichurna in the management of Tamaka Shwasa. The Pharma Innovation Journal 2018;7(6):516–518.
Ghoke, S.S. “Evaluation of Antiviral Activity of Ocimum sanctum and Acaica Arabica leaves extracts against H9N2 virus using embryonated chicken egg model.” BMC complementary and alternative medicine 2018;174.
Usha Patil. Studies on antiviral activity of tulsi (ocimum sanctum) crude exractson selected viruses of veterinary importance. International Journal of Ayurveda And Pharma Research. 2018;6(4):17–21.
Benencia, F., and M. C. Courreges. In vitro and in vivo activity of eugenol on human herpes virus. Phytotherapy Research: An International Journal Devoted To Pharmacological And Toxicological Evaluation Of Natural Product Derivatives; 2000:495–500.
Yucharoen, Raenu, Songyot Anuchapreeda, and Yingmanee Tragoolpua. Antiherpes simplex virus activity of extracts from culinary herbs Ofocimum sanctum l, Ocimumbasilicum l. and Ocimumamericanum l. African Journal of Biotechnology 10.5 (2011):860–866.
Goel, Anjana. Invitro antiviral potential of ocimum sanctum leaves extract against new castle disease virus of poultry. International Journal of Microbiology And Immunology Research. 2013;51–55.
Kumar, Amit. Ocimum sanctum (Tulsi): a miracle herb and boon to medical science- A Review. Int J Argon Plant Prod. 2013;4(7):1580–9.
Badam L. S. P. Joshi, and S. S. Bedekar. In vitro antiviral activity of neem (Azadirachtaindica A. Juss) leaf extract against group B coxsackieviruses.” The Journal of Communicable Diseases 1999;31(2):79–90.
Trivedi A, Fatima N, Husain I, Misra A. An Update on Therapeutic Potential of Neem and Its Active Constituents: A Panacea For All Diseases. Era J. Med. Res. 2019;6(1):1–8.
Imrana, Ishrat, et al. Invitro evaluation of Antiviral activity of leaf extracts of Azadirachtaindica, Moringaoleifera and Morus alba against the foot and mouth disease virus on BHK-21 cell line. Scienceasia 2016; 42(6): 392–396.
Parida M. M. Inhibitory potential of neem (Azadirachtaindica) leaves on dengue virus type-2 replication. Journal of Ethnopharmacology 2002; 79(2):273–278.
Dhama K, Sachan S, Khandia R, Munjal A, Iqbal HMN, LAtheef SK, et al. Medicinal and Beneficial Health Applications of Tinosporacordifolia (Guduchi): A Miraculous herb Countering Various Diseases/Disorders and its Immunomodulatory effects. 2017;10(2):96–111.
Liang-Tzung L, Wen-Chang H, Chung-Chin, L. Antiviral Natural Products and Herbal Medicines. Journal of Traditional and Complementary Medicine, 2014;4(1):24–35.
Alschuler L, Weil A, Horwitz R, Stamets P, Chiasson A, Crocker R et al. Integrative considerations during the COVID-19 pandemic. EXPLORE. 2020.
Ling C. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). Journal of Integrative Medicine. 2020;18(2):87–88.
Ren J, Zhang A, Wang X. Traditional Chinese medicine for COVID-19 treatment. Pharmacological Research. 2020;155:104743.
Yang Y, Islam M, Wang J, Li Y, Chen X. Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective. International Journal of Biological Sciences. 2020;16(10):1708–1717.
Li Ni. Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan. Frontiers of Medicine. 2020.
Tripathi A, Srivastava SK. Ecofriendly treatment of azo dyes: biodecolorization using bacterial strains. International Journal of Bioscience, Biochemistry and Bioinformatics. 2011;1(1):37.
Brooijmans N, Kuntz ID. Molecular recognition and docking algorithms. Annual review of biophysics and biomolecular structure. 2003;32(1):335–73.
Bagchi A, Gopakumar R. Galilean conformal algebras and AdS/CFT. Journal of High Energy Physics. 2009;(07):037.
Timmerman R, Paulus R, Galvin J, Michalski J, Straube W, Bradley J, Fakiris A, Bezjak A, Videtic G, Johnstone D, Fowler J. Stereotactic body radiation therapy for inoperable early stage lung cancer. Jama. 2010;303(11):1070–6.
Preenon Bagchi, Nikita Sinha, Ajit Kar, and Mahesh. M Ayur-Informatics: Establishing an Ayurvedic Remedy for Bronchial Carcinoma IJBBB 2011 1(1):41–46
Zhenming Jin, Xiaoyu Du, et al. Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Natureresearch. 2020.
Chandel V, Raj S, Rathi B, Kumar D. In Silico Identification of Potent COVID-19 Main Protease Inhibitors from FDA Approved Antiviral Compounds and Active Phytochemicals through Molecular Docking: A Drug Repurposing Approach. 2020.
Ramaiah M, Vishwakarma R, Shaanker R. Molecular Docking analysis of selected natural products from plants for inhibition of SARS-CoV-2 main protease. Current science. 2020;118(7):1087–1092.
In silico Identification of Potent COVID-19 Main Protease Inhibitors from FDA approved Antiviral Compounds and Active Phytochemicals through Molecular Docking: A Drug Repurposing Approach Vaishali Chandel1, Sibi Raj1, Brijesh Rathi2, Dhruv Kumar1,*
Balakrishna A, Pokhrel S, Singh J, Varshney A. Withanone from Withania somnifera may inhibit novel coronavirus (covid-19) entry by disrupting interactions between viral s-protein receptor binding domain and host ACE-2 receptor. Virology. 2020
Anuya A, Anil R, Abhay SC. Evaluation of Ocimum sanctum and Tinosporacordifolia as Probable HIV-Protease Inhibitors. International Journal of Pharmaceutical Sciences Review and Research. 2014;25(1):315–318.
Zhi Cai, Guoyin Zhang, Bin Tang, Yan Liu, Xiaojing Fu, Xuejin Zhang. Promising Anti-influenza Properties of Active Constituent of Withaniasomnifera Ayurvedic Herb in Targeting Neuraminidase of H1N1 Influenza: Computational Study. Cell Biochemistry and Biophysics. 2015;72: 727–739.
Obata Y, Furusawa Y, Hase K. Epigenetic modifications of the immune system in health and disease. Immunol. Cell Biol. 2015;93:226–232.
Busslinger M., Tarakhovsky A. Epigenetic control of immunity. Cold Spring Harb. Perspect. Biol. 2014;6
Collins FS, Morgan M, Patrinos A. The Human Genome Project: Lessons from large-scale biology. Science. 2003;300:286–290.
Rivera CM, Ren B. Mapping human epigenomes. Cell. 2013;155:39–55.
Rakyan VK, Down TA, Balding DJ, Beck S. Epigenome-wide association studies for common human diseases. Nat. Rev. Genet. 2011;12:529–541.
Birney E, Smith GD, Greally JM. Epigenome-wide Association Studies and the Interpretation of Disease -Omics. PLoS Genet. 2016;12:e1006105.
Consortium EP, Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, etal.: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007;447:799–816.
Schäfer A, Baric RS. Epigenetic landscape during coronavirus infection. Pathogens. 2017 Mar;6(1):8.
Sardar R, Satish D, Birla S, Gupta D. Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis. bio Rxiv. 2020 Jan 1.